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子宫内膜间质肉瘤(ESS),是发生于子宫的恶性肿瘤.根据肿瘤的恶性程度和生物学行为,可分为低度恶性子宫内膜间质肉瘤(LGESS)和高度恶性子宫内膜间质肉瘤(HGESS).早期可行病理活检诊断,辅以影像学检查和免疫组化.目前临床上缺乏对ESS的规范化治疗方案,多采用手术联合术后辅助治疗的综合治疗方法.内分泌治疗是重要的治疗方法之一,尤其对高表达雌、孕激素受体的LGESS.靶向治疗作为新的治疗方法需要进一步研究探讨.本文对近年来国内外ESS的新进展进行综述,希望为临床治疗提供帮助.“,”Endometrial stromal sarcoma (ESS) is a kind of malignancy of uterus.According to the grade of the malignancy and its biological behavior,the tumors are divided into low grade endometrial stromal sarcoma (LGESS) and high grade endometrial stromal sarcoma (HGESS).In early stage,pathological diagnosis biopsy can be actualized,supplemented with imaging examination and immunohistochemistry.So far,there is a lack of standardized treatment for ESS in clinic,and the combined therapy of surgery and postoperative adjuvant therapy is mostly used.Endocrine therapy is one of the important treatment methods,especially in the LGESS which highly expressed estrogen and progesterone receptor.Targeted therapy,being a new treatment,needs further study and discussion.This article reviews the latest development of ESS in recent years,hoping to provide help for clinical treatment.