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目的探讨伴有中央颞区棘波的良性癫(BECTS)及脑电图癫样放电对儿童智力的影响。方法对42例BECTS患儿(BECTS组)应用中国韦氏儿童智力量表进行智力测定,与21例年龄、性别、受教育情况及家庭背景相匹配的呼吸道感染儿童(对照组)进行比较;并将其临床资料(包括起病年龄、病程、发作频率及脑电图的放电频率等)按不同等级分类后进行相关性分析,使用SPSS13.0软件观察各种因素对BECTS患儿智力的影响。结果BECTS组患儿各项智商均值均低于对照组,且言语智商和总智商均值和对照组比较差异均有统计学意义(Pa<0.05);BECTS组病程与言语智商、总智商具有相关性(Pa<0.05);BECTS患儿清醒期脑电图的异常放电频率与言语智商、总智商具有相关性(Pa<0.05),而其思睡期及非快动眼睡眠期无相关性。结论BECTS患儿与对照儿童相比,智力水平下降,且言语智商受损更为明显。病程和清醒期脑电图异常放电频率影响BECTS患儿的智力水平,尤其是对言语智商的影响更为显著。
Objective To investigate the effects of benign epilepsy (BECTS) accompanied by centrotemporal spikes and epileptiform discharges on the intelligence of children. Methods Forty-two children with BECTS (BECTS group) were assessed by using the Wechsler Intelligence Scale of Children in China with 21 children with respiratory tract infection (control group) who were matched in age, sex, education and family background. The clinical data (including the age of onset, duration of disease, frequency of seizures and discharge frequency of EEG) were classified according to different levels for correlation analysis. SPSS 13.0 software was used to observe the effects of various factors on the intelligence of BECTS children. Results The average IQ of children in BECTS group was lower than that of control group, and the mean of speech IQ and total IQ was significantly different from that of control group (P0.05). The duration of BECTS group was related to speech IQ and total IQ (P <0.05). The frequency of abnormal discharge in conscious patients with BECTS was correlated with verbal IQ and total IQ (Pa <0.05), while there was no correlation between sleep-deprived and non-REM sleep. Conclusions Compared with control children, children with BECTS have lower level of intelligence and more impairment of speech and IQ. The course of disease and the frequency of anomalous discharge of EEG affect the level of intelligence of BECTS children, especially the speech IQ more significantly.