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目的 分析我国小儿重症肌无力 (MG)的临床特点。方法 回顾性分析 195 6～ 1999年诊治的 1381例小儿MG病例资料 ,并与同时期诊治的 10 6 9例成人期MG进行对比。结果 同期小儿MG的患病人数较成人多 ,性别差异较小 ,发病年龄以 1～ 5岁为主 ,因各类药物、感染及外伤而诱发或加重者较多 ,以眼肌症状首发者多见 ,改良Osserman分型以Ⅰ型为主 ,危象发生率及病死率低 ,合并胸腺瘤者少见。结论 本文小儿MG的临床特点不同于成人期及国外报道 ,充分认识此特点将有利于指导临床的诊断和治疗。
Objective To analyze the clinical features of pediatric myasthenia gravis (MG) in China. Methods The data of 1381 cases of pediatric MG treated in our hospital from 1996 to 1999 were retrospectively analyzed and compared with that of 1069 adult patients diagnosed and treated at the same period. Results In the same period, the prevalence of MG in children was higher than that of adults, and the gender difference was small. The age of onset was mainly from 1 to 5 years old, and more were induced or aggravated by various drugs, infections and trauma. See, modified Osserman type Ⅰ-based, the incidence of crisis and mortality is low, rare cases of thymoma. Conclusion The clinical features of pediatric MG are different from those reported in adulthood and foreign countries. A full understanding of this feature will help to guide the clinical diagnosis and treatment.