创伤病人预防性应用抗生素治疗,由于体液的大量转移和生理反应活动的亢进,可有很大的变化。本文作者对150名需要剖腹的腹部伤病人选用氯洁霉素加丁胺卡那霉素预防感染作前瞻性研究,以分析用药的时程、间隔和剂量对预防感染的影响。将150名在急诊室已静注氯洁霉素1200mg和丁胺卡那霉素7.5 mg/kg的手术高危感染病人随机分成三组:组Ⅰ12小时后加氯洁霉素(1200mg)和丁胺卡那霉素(7.5mg/kg)治疗(即24小时疗法);组Ⅱ每12小时重复氯洁霉素 Prophylactic antibiotic treatment of traumatic patients, due to the large body fluid transfer and hyperthyroidism, may have a lot of changes. The authors selected prospective study of clonidine and amikacin to prevent infection in 150 abdominal trauma patients who needed caesarean section to analyze the effects of time course, interval and dose on the prevention of infection. 150 high-risk surgical patients with clindamycin 1200 mg and amikacin 7.5 mg / kg intravenously in the emergency room were randomly assigned to three groups: Group I 12 hours later clindamycin (1200 mg) and butylamine Kanamycin (7.5 mg / kg) treatment (ie, 24-hour therapy); group II repeated every 12 hours clindamycin