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目的:分析纳洛酮用于治疗感染性休克时对患者肾脏功能的影响。方法:选择ICU感染性休克患者43例,其中21例在治疗过程中使用了纳洛酮,为A组;另22例为按照病情相近、病因相同、年龄相仿的原则选取的未使用纳洛酮者作为对照,为B组。分析比较两组患者肾功相关指标的变化。结果:治疗前,所有患者均有少尿,尿白蛋白、尿β2-微球蛋白定量及血尿素氮和肌酐水平均明显高于正常,但两组之间比较均无显著性差异;经过治疗,所有患者的尿量、血尿素氮和肌酐水平均恢复到正常水平,而尿白蛋白、尿β2-微球蛋白定量明显下降,以A组患者的下降更为显著。结论:纳洛酮用于感染性休克患者时,对肾脏功能有一定的保护作用。
Objective: To analyze the effect of naloxone on renal function in patients with septic shock. Methods: Forty-three patients with ICU septic shock were selected, of whom 21 were treated with naloxone in the course of treatment, group A, and 22 were unadulterated naloxone according to similar illness, same cause and same age As a control, for the B group. Analyze and compare the changes of renal related index in two groups. Results: Before treatment, all patients had oliguria, urinary albumin, urine β2-microglobulin quantitative and blood urea nitrogen and creatinine levels were significantly higher than the normal, but no significant difference between the two groups; after treatment , All patients’ urine volume, blood urea nitrogen and creatinine levels returned to normal levels, while urinary albumin, urinary β2-microglobulin quantitatively decreased significantly to A group of patients was more significant decline. Conclusion: Naloxone has some protective effects on renal function in patients with septic shock.