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基因芯片技术对肿瘤基因组学的研究提供了一种高效的手段 .采用基因芯片技术观察了 14例初发急性髓系白血病患者 12 80 0条基因的表达谱 ,找到了一些和白血病发生有密切关系的基因 .用表达谱的聚类方法分析难治性白血病的基因表达特征 ,发现一些与耐药相关的基因在难治性白血病人和易治性白血病人中表达有明显不同 ,证明难治性白血病与耐药有一定关系 .
Gene chip technology provides an efficient means for the study of tumor genomics.We observed the gene expression profiles of 12 80 genes in 14 patients with acute myeloid leukemia using gene chip technology and found some closely related to the occurrence of leukemia Of the gene expression profiles of cluster analysis of refractory leukemia gene expression characteristics and found that some of the resistance-related genes in refractory leukemia and easy-to-treat leukemia in patients with significantly different expression, proved refractory Leukemia and resistance have a certain relationship.