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目的 评价大剂量硫酸镁治疗重度妊娠高血压综合征的效果。方法 我院产科于2002年11月～ 2004年6月对重度妊高征且伴有严重颅内压增高症状之孕妇26例,首先静脉注射硫酸镁5g及地西泮10mg,同时 口服降压药治疗,之后连续静脉滴注硫酸镁1.5g/h,应用至60g,停止用药。3～5天后如病情反复可进行第二个疗 程治疗,观察症状、血压、尿蛋白定量、水肿及血生化检查等各项指标。结果 症状、血压、尿蛋白定量、水肿及血生 化检查等各项指标均有明显改善;早产儿、新生儿窒息、NRDS、新生儿缺血缺氧性脑病的发生率明显低于对照组, 差异显著,且无一例新生儿死亡。取得了较好的临床效果。结论 大剂量硫酸镁治疗重度妊高征效果显著,可明 显降低孕产妇病死率,延长孕龄,降低新生儿病死率及早产发生率。
Objective To evaluate the effect of high dose magnesium sulfate on severe pregnancy induced hypertension. Methods The obstetrics and gynecology in our hospital from November 2002 to June 2004 for severe pregnancy-induced hypertension and severe symptoms of increased intracranial pressure in 26 pregnant women, first intravenous injection of 5g magnesium sulfate and diazepam 10mg, while oral antihypertensive drugs Treatment, followed by continuous intravenous infusion of magnesium sulfate 1.5g / h, applied to 60g, stop medication. 3 to 5 days later, as the disease can be repeated for the second course of treatment, observe the symptoms, blood pressure, urine protein, edema and blood biochemical tests and other indicators. Results Symptoms, blood pressure, urine protein quantitation, edema and blood biochemical tests and other indicators were significantly improved; premature children, neonatal asphyxia, NRDS, the incidence of neonatal hypoxic ischemic encephalopathy was significantly lower than the control group, the difference Significant, and no newborn deaths. Has achieved good clinical results. Conclusion High-dose magnesium sulfate treatment of severe pregnancy-induced hypertension significantly, can significantly reduce maternal mortality, prolonged gestational age, reduce neonatal mortality and the incidence of preterm birth.