Pianese(1903年)首先创用套管针在腓骨骨骺进行骨髓穿刺术,Ghedini(1908)年在胫骨上三分之一部位进行骨髓环钻术,Seyfarth(1923年)选择胸骨作环钻术,从1929年Arinkin使用骨髓穿刺针抽吸髓液涂片作为血液病的检查方法以来,骨髓活检似乎已由骨髓穿刺涂片检查所代替。但是由于抽吸骨髓往往被窦血所稀释,Berlin用同位素检查稀释度为40～100%,有时干抽或抽出的髓液不能确切地代表骨髓细胞的增殖情况;而骨髓活检组织切片可以观察造血组织的完整结构包括细胞的多寡及其分布、脂肪组织、有无肿 Pianese (1903) first used a trocar for bone marrow puncture in the fibula epiphysis, Ghedini (1908) performed a bone marrow loop in the upper third of the tibia, Seyfarth (1923) selected the sternum for ring drilling, Bone marrow biopsy appears to have been replaced by a bone marrow biopsy since Arinkin used a bone marrow aspirate to aspirate a smear of bone marrow in 1929 as a blood test. However, due to the suction of bone marrow is often diluted by sinus blood, Berlin with isotopes to check the dilution of 40 to 100%, sometimes pumping or pumping out of the marrow can not accurately represent the proliferation of bone marrow cells; and bone marrow biopsy can observe the hematopoietic tissue sections The complete structure of the organization, including the number of cells and their distribution, adipose tissue, with or without swelling