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两性霉素B脂质体(L-AmpB)与未包封脂质体的两性霉素B((F-AmpB)的小鼠急毒试验LD_(50)分别为5．07mg·kg_(-1)和2．61mg·kg_(-1)。对全身性白色念珠菌感染的实验治疗,两者等剂量(1．0mg·kg_(-1)),小鼠存活率分别为55%和35%,差别不明显(p>0．05)。当F-AmpB剂量增加1．2mg·kg_(-1),大部分动物死亡,而L-AmpB加大至2．0mg·kg_(-1)和3．0mg·kg_(-1),存活率分别达到75%与85%,与F-AmpBl．0mg·kg_(-1)相比差别明显(p<0．01)。将各组存活动物饲养60天,取肾脏制成匀浆,进行真菌培养,除L-AmpB3．0mg·kg_(-1)组未见真菌生长外,其余各组均为阳性,提示:3．0mg·kg_(-1)可达根治效果。
The acute toxicity test (LD50) of amphotericin B liposome (L-AmpB) and liposome-free amphotericin B (F-AmpB) were 5.07 mg · kg -1 ) And 2.61 mg · kg -1 (1). The experimental treatment of systemic Candida albicans infection, the two doses (1.0mg · kg _ (-1)), the survival rate of mice were 55% and 35% (P> 0.05) .When the dose of F-AmpB was increased by 1.2 mg · kg -1, most animals died while L-AmpB increased to 2.0 mg · kg -1 3.0mg · kg -1, the survival rate reached 75% and 85%, respectively, which was significantly different from that of F-AmpB 1.0mg · kg -1 (p <0.01) After 60 days, the kidneys were homogenized and cultured in fungi. No fungal growth was observed in the L-AmpB 3.0 mg · kg -1 group, and all the other groups were positive, suggesting that: 3.0 mg · kg -1 ) Up to the radical effect.