论文部分内容阅读
pH-responsive-chitosan nanoparticles for the control release of protein drug were prepared by combining two-step crosslinking method,in which chitosan was subsequently crosslinked by sodium tripolyphosphate(TPP)and glycidoxypropyltrimethoxysilane (GPTMS).Compared with TPP crosslinked chitosan particles,the two-step crosslinked nanoparticles were not only pH-responsive but also more stable in wide pH range.Fluorescein isothiocyanate(FITC)labeled anti-human-IgG antibody was used as a model protein drug for evaluating the control release profile of the nano-carrier.The amount of released antibody increased from 5.6%to 50%when the pH of solution shifted from 7.4 to 6.0.The results suggest the possible application of the nanoparticles as pHresponsive drug delivery materials.
pH-responsive-chitosan nanoparticles for the control release of protein drug were prepared by combining two-step crosslinking method, which chitosan was crosslinked by sodium tripolyphosphate (TPP) and glycidoxypropyltrimethoxysilane (GPTMS) .Compared with TPP crosslinked chitosan particles, the two -step crosslinked nanoparticles were not only pH-responsive but also more stable in a wide pH range. Fluorescein isothiocyanate (FITC) labeled anti-human-IgG antibody was used as a model protein drug for evaluating the control release profile of the nano-carrier. The amount of released antibody increased from 5.6% to 50% when the pH of the solution shifted from 7.4 to 6.0. The results suggest the possible application of the nanoparticles as pH responsive drug delivery materials.