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目的:探讨多囊卵巢综合征经腹腔镜治疗后实行体外受精-胚胎移植的临床效果。方法:对24例耐氯米芬的患者分成两组,14例为IVF-ET组:实行体外受精—胚胎移植治疗;10例为LOP/IVF-ET组:实施腹腔镜卵巢打孔后,半年未孕者实施体外受精-胚胎移植。观察两组促排卵药物的用量、用药天数,HCG日血E2、FSH、LH水平,所取卵子数目、受精率、优质胚胎率、临床妊娠率及卵巢过度刺激征发生率。结果:两组患者r-FSH用量及Gn天数LOP/IVF-ET组明显高于IVF-ET组(P<0.05);HCG日血E2水平LOP/IVF-ET组明显低于IVF-ET组(P<0.05);获卵数LOP/IVF-ET组明显少于IVF-ET组(P<0.05),受精率、卵裂率、优质胚胎数、临床妊娠率均无明显差异(P>0.05)。两组患者均无重度OHSS发生,轻及中度OHSS发生率IVF-ET组明显高于LOP/IVF-ET组(P<0.05)。结论:腹腔镜打孔术后1年行IVF-ET治疗,可明显提高IVF-ET治疗效果,降低OHSS的发生率。
Objective: To investigate the clinical effect of IVF-ET after laparoscopic treatment of PCOS. Methods: Twenty-four patients with clomiphene citrate were divided into two groups. Fourteen patients were treated with IVF-ET: In vitro fertilization-embryo transfer and LOP / IVF-ET were performed in 10 patients. After laparoscopic ovarian drilling, Infertility carries out in vitro fertilization - embryo transfer. The amount of ovulation induction drugs, the number of days of treatment, E2, FSH and LH levels, the number of oocytes retrieved, fertilization rate, high quality embryo rate, clinical pregnancy rate and ovarian hyperstimulation rate were observed. Results: The levels of r-FSH and Gn-day LOP / IVF-ET in both groups were significantly higher than those in IVF-ET group (P <0.05) (P <0.05). There was no significant difference in fertilization rate, cleavage rate, number of high quality embryos and clinical pregnancy rate between LOP / IVF-ET group and IVF-ET group (P <0.05) . There was no severe OHSS in both groups. The incidence of mild and moderate OHSS in IVF-ET group was significantly higher than that in LOP / IVF-ET group (P <0.05). Conclusion: IVF-ET treatment one year after laparoscopic drilling can significantly improve the therapeutic effect of IVF-ET and reduce the incidence of OHSS.