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肠型脂肪酸结合蛋白是脂肪酸结合蛋白家族的一员,其特异性地存在于小肠中,在脂肪酸的吸收和细胞内的转运中起着重要作用,近来研究发现其与新生儿坏死性小肠结肠炎、乳糜泻、肠道成熟度及代谢性疾病等密切相关,该文就小肠型脂肪酸结合蛋白的基因结构和蛋白分子结构、生理作用和作用机制以及其与肠道和代谢性疾病关系进行综述。
Intestinal fatty acid-binding protein is a member of the fatty acid binding protein family, which is specifically present in the small intestine and plays an important role in fatty acid absorption and intracellular transport. Recent studies have found that it is associated with neonatal necrotizing enterocolitis , Celiac disease, intestinal maturity and metabolic diseases. This review summarizes the gene structure, protein molecular structure, physiological role and mechanism of small intestine fatty acid binding protein and its relationship with intestinal and metabolic diseases.