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用巨噬细胞吞噬酵母菌的方法检测吞噬粉尘后大鼠肺泡巨噬细胞功能。发现:云锡氧化矿尘、云锡硫化矿尘、香花岭矿尘、二氧化硅尘、宣威煤烟尘等五种粉尘不同程度地抑制巨噬细胞的吞噬功能。SiO_2在染尘后第二周即有改变。其它生产性粉尘均在染尘后3～6周致肺泡巨噬细胞吞噬功能下降,并在第6周仍维持较低水平。结果表明:云锡等生产性粉尘对大鼠肺泡巨噬细胞的吞噬功能有抑制作用,从而使体内非特异免疫受到影响,破坏免疫监视系统,这可能是促使肺癌发生和发展的一个有利因素之一。
Phagocytic dust was used to detect the alveolar macrophage function in macrophages by phagocytizing yeast. It was found that five kinds of dust, such as cloud tin oxide mine dust, cloud tin sulfide mine dust, Xianghualing mine dust, silica dust and Xuanwei coal dust, inhibited phagocytosis of macrophages to varying degrees. SiO 2 in the second week after the dust has changed. Other productive dusts reduced the phagocytic function of alveolar macrophages 3 to 6 weeks after dusting, and remained low at the 6th week. The results showed that production dusts such as tin and tin could inhibit the phagocytosis of alveolar macrophages in rats, which would affect the non-specific immunity in vivo and destroy the immune surveillance system, which may be a favorable factor to promote the occurrence and development of lung cancer one.