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系统性红斑狼疮(SLE)患者的中枢神经系统(CNS)损害发生率很高,临床症状各式各样.这种中枢神经损害通常以血管病变为主,最具特征性的是主要在终末动脉至毛细血管部位发生的血管玻璃样变、管周细胞浸润和内膜肥厚,且常有多发性微小梗塞.但是,真正的血管炎很少见.据UCLA医疗中心的报告,临床诊断为CNS狼疮的57例尸检结果为,65%有血管病变,其中梗塞44%,出血42%,感染28%.镜下所见,血管玻璃样变54%,血管周围细胞浸润28%,内膜增厚21%,血栓形成7%,血管炎8%.梗塞病例几乎都是微小梗塞.在出血病例中,蛛网膜下出血30%,微小出血19%,脑内出血10%,硬膜下出血4%.
Patients with systemic lupus erythematosus (SLE) have a high incidence of central nervous system (CNS) damage and a wide range of clinical symptoms, which are usually predominantly vascular lesions, most notably at the terminal Arterial to capillaries with vascular glassy changes, peritubular infiltration and intima hypertrophy, and often multiple micro-infarcts However, the real vasculitis is rare.According to UCLA Medical Center report, the clinical diagnosis of CNS 57 cases of lupus autopsy results, 65% of vascular lesions, of which 44% of infarctions, bleeding 42%, infection 28%. Microscopically, vascular glassy metastasis 54%, perivascular cell infiltration 28%, intimal thickening 21%, thrombosis 7%, vasculitis 8. Infarction cases are almost all small infarcts.In the bleeding cases, subarachnoid hemorrhage 30%, 19% minor bleeding, intracerebral hemorrhage 10%, 4% of subdural hemorrhage.