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目的探讨奥美拉唑联合硫糖铝治疗急性出血性胃炎的临床疗效。方法选取张家界市人民医院2014年1月—2016年4月收治的急性出血性胃炎患者140例,随机分为对照组和观察组,各70例。患者入院后均给予常规内科治疗,对照组患者给予奥美拉唑+0.9%氯化钠溶液静脉滴注;观察组患者在对照组基础上联合硫糖铝治疗,两组患者均持续治疗1周。比较两组患者治疗24、48、72 h再出血情况、出血量、输血量、止血时间及住院时间,并观察两组患者治疗期间不良反应发生情况。结果观察组患者治疗24、48、72 h再出血率均低于对照组(P<0.05)。观察组患者出血量、输血量少于对照组,止血时间、住院时间短于对照组(P<0.05)。两组患者治疗期间均未见严重不良反应。结论奥美拉唑联合硫糖铝治疗急性出血性胃炎的临床疗效确切,可有效降低再出血率,减少患者出血量及输血量,缩短止血时间及住院时间,且安全性好。
Objective To investigate the clinical efficacy of omeprazole and sucralfate in the treatment of acute hemorrhagic gastritis. Methods 140 patients with acute hemorrhagic gastritis admitted from January 2014 to April 2016 in Zhangjiajie People’s Hospital were randomly divided into control group and observation group, with 70 cases in each group. Patients were given conventional medical treatment after admission, the control group of patients given omeprazole + 0.9% sodium chloride solution intravenous infusion; observation group patients in the control group based on the combination of sucralfate, two groups of patients were treated for 1 week . The rebleeding, bleeding, transfusion volume, bleeding time and length of hospital stay were compared between the two groups in 24, 48, and 72 hours of treatment. The incidence of adverse reactions in the two groups was also observed. Results In the observation group, the rebleeding rates at 24, 48 and 72 h were lower than those in the control group (P <0.05). The amount of bleeding in the observation group was less than that in the control group, and the bleeding time and hospital stay were shorter than those in the control group (P <0.05). No serious adverse reactions were observed during treatment in both groups. Conclusion Omeprazole combined with sucralfate is effective in the treatment of acute hemorrhagic gastritis. It can effectively reduce the rate of rebleeding, reduce the amount of bleeding and transfusion, shorten the time to hemostasis and hospital stay, and has good safety.