【摘 要】
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AIM: To investigate the changes of lymphocyte subpopulations, especially CD4+CD25+ T regulatory cells in Smad3-/- mice.METHODS: Hematological changes and change
【机 构】
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Department of Immunology,Third Affiliated Hospital of Xinxiang Medical College,Institute of Biotechn
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AIM: To investigate the changes of lymphocyte subpopulations, especially CD4+CD25+ T regulatory cells in Smad3-/- mice.METHODS: Hematological changes and changes of lymphocyte subpopulations were detected in Smad3-/- mice using cell counter and flow cytometry, respectively, and compared to their littermate controls.RESULTS: The numbers of neutrophils and lymphocytes in peripheral blood were significantly increased in Smad3-/- mice compared to littermate controls. CD19+expressing cells in blood and spleen, and CD8+ T cells in thymus were all markedly decreased in Smad3-/- mice. More important, Smad3-/- mice had an increased population of CD4+CD25+ T cells in peripheral lymphoid tissues,including thymus, spleen, and lymph nodes.CONCLUSION:These observations suggest that the changes of lymphocyte subpopulations might play a role in susceptibility to inflammation of Smad3-/- mice.
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