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角化细胞生长因子(KGF 或 FGF-7)是成纤维细胞生长因子(FGF)家族中的第七个成员, 它介导多种组织中表(上)皮细胞增殖和分化。本文对 KGF 研究中如下几个问题进行了综述,(1)KGF 作用通路:已有实验表明在间充质-表皮相互作用中 KGF 主要通过的旁分泌通路进行调节,此时 KGF表达受到反馈环调节,KGF 特别在肿瘤发生过程中通过自分泌途径进行功能调控;(2)细胞凋亡中的 KGF:少数研究近期揭示 KGF 基于自身促细胞分裂功能介导细胞存活,而且KGF 通过 Nrf-2 通路抑制在 ROS 诱导的凋亡;(3)肿瘤发生中的 KGF:高表达的 KGF 促进肿瘤细胞和多种癌症的进展、扩散和侵染,并伴有自分泌通路替代旁分泌,另外很清楚的是 KGF 在乳腺癌进展过程中起早期信号作用;(4)KGF 临床应用和给药方法:KGF 已成功用于治疗多起放疗和化疗诱导的粘膜炎,并被研发成皮下注射药品(Palifermin),但是更有效的给药方法仍在研究之中。参 51。
Keratinocyte growth factor (KGF or FGF-7) is the seventh member of the fibroblast growth factor (FGF) family that mediates epidermal (epidermal) cell proliferation and differentiation in a variety of tissues. Here are some of the issues in the KGF study: (1) KGF pathway: It has been experimentally shown that KGF is mainly regulated by the paracrine pathway in mesenchymal-epidermal interactions where KGF expression is regulated by a feedback loop Regulation, KGF is functionally regulated through autocrine pathways in particular during tumorigenesis; (2) KGF in apoptosis: A few studies have recently revealed that KGF mediates cell survival based on its own mitogenic function and that KGF mediates cell viability through the Nrf-2 pathway Inhibition of ROS-induced apoptosis; (3) KGF in tumorigenesis: Highly expressed KGF promotes the progression, spread, and invasion of tumor cells and various cancers, accompanied by an autocrine pathway that replaces paracrine and yet clearly Is an early signal of KGF in the progression of breast cancer. (4) Clinical application and administration of KGF: KGF has been successfully used in the treatment of multiple radiotherapy and chemotherapy-induced mucositis and has been developed as a subcutaneous injection of drug (Palifermin) , But more effective methods of administration are still under study. Participation 51.