Primary liver liposarcoma is a rare disease.Because ofits rarity,the knowledge of the clinical course,manage-ment,and prognosis of primary liver liposarcoma are alllimited for clinicians.A 61-year-old female patient whosuffered from a huge primary liposarcoma in the centralportion of the liver had the clinical presentations offever,nausea,vomiting,jaundice,and body weight loss.The huge tumor was resected successfully.However,the tumor recurred repeatedly and she had repeatedhepatectomies to remove the tumor.The tumor becameaggravating after repeated surgeries.Eventually,thepatient had cervical spinal metastasis of liposarcoma andshe survived for 26 months after liver liposarcoma wasdiagnosed.Although the tumor may become aggrava-ting after repeated surgeries,repeated hepatectomiesare still the best policy to achieve a long-term survivalfor the patients. Primary liver liposarcoma is a rare disease. The knowledge of the clinical course, manage-ment, and prognosis of primary liver liposarcoma are all limited for clinicians. A 61-year-old female patient whosuffered from a huge primary liposarcoma in the centralportion of the liver had the clinical presentations offever, nausea, vomiting, jaundice, and body weight loss. The huge tumor was resected successfully. Despite, the tumor recurred repeatedly and she had repeatedhepatectomies to remove the tumor. The tumor became aggravating after repeated surgeries. Eventually, thepatient had cervical spinal metastasis of liposarcoma and survivors for 26 months after liver liposarcoma wasdiagnosed. Although the tumor may become aggrava-ting after repeated surgeries, repeated hepatectomiesare still the best policy to achieve a long-term survival for the patients.