在骨的正常发育及病理情况下均有骨细胞凋亡的参与。雌激素分泌减少与绝经后骨质疏松的发生密切相关,并且直接或间接地影响了骨细胞的凋亡。探明参与骨细胞凋亡的基因及其调控基因,有助于寻找一条基因治疗骨质疏松的新途径。 Bone cell apoptosis is involved in the normal development of bone and pathological conditions. The decrease of estrogen secretion is closely related to the occurrence of postmenopausal osteoporosis, and directly or indirectly affects the apoptosis of osteocytes. Probing the genes involved in apoptosis of osteocytes and their regulatory genes help to find a new way of gene therapy for osteoporosis.