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目的探讨门诊药师干预前、后本院药品不良反应(ADR)报告情况。方法选取湘潭市中心医院2015年1月—2016年6月门诊上报的ADR报告601例。于2015年9月建立门诊药师处方审核管理系统,对门诊处方进行审核评价。干预前上报ADR报告315例与干预后ADR报告286例。比较干预前后ADR患者年龄与性别分布、药品种类、给药途径及对特殊咨询案例进行分析。结果干预后上报ADR报告数少于干预前。干预前后ADR患者性别、年龄比较,差异无统计学意义(P>0.05)。干预前后发生ADR的药品种类主要集中在抗感染药物、中药注射剂、抗肿瘤药物和心脑血管药物中。干预前后ADR药品种类比较,差异无统计学意义(P>0.05)。干预前后发生ADR的给药途径主要为静脉给药。干预前后给药途径比较,差异无统计学意义(P>0.05)。结论临床药师在门诊ADR的干预中发挥着重要作用,可减少ADR发生,促进合理用药。
Objective To investigate the prevalence of adverse drug reactions (ADR) reported by outpatient pharmacists before and after intervention. Methods Sixty - one ADR cases were reported from outpatients in Central Hospital of Xiangtan from January 2015 to June 2016. In September 2015, an outpatient pharmacist prescription review and management system was established to review and evaluate outpatient prescriptions. 315 cases of ADR before intervention and 286 cases of ADR after intervention. ADR patients before and after the comparison of age and gender distribution, drug type, route of administration and analysis of special counseling cases. Results The number of ADR reports after intervention was less than before intervention. ADR patients before and after intervention of gender, age, the difference was not statistically significant (P> 0.05). ADR occurred before and after intervention in the types of drugs are mainly concentrated in anti-infectives, Chinese medicine injection, anti-tumor drugs and cardiovascular drugs. ADR before and after the intervention of drug types, the difference was not statistically significant (P> 0.05). ADR before and after the main route of administration for intravenous administration. Before and after the intervention route of administration, the difference was not statistically significant (P> 0.05). Conclusion Clinical pharmacists play an important role in the intervention of clinic ADR, which can reduce the occurrence of ADR and promote rational drug use.