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目的观察复方丹参注射液湿敷联合氦氖激光治疗新生儿输液所致静脉炎的临床疗效及机制。方法采用随机分组的方法,将80例新生儿输液所致静脉炎患儿分为两组:复方丹参注射液湿敷联合氦氖激光治疗为治疗组(n=40)、50%硫酸镁湿敷联合氦氖激光治疗为对照组(n=40)进行5d的治疗,于治疗开始、第6天进行临床评估,同时检测血小板聚集率。结果治疗前,新生儿输液所致静脉炎患儿血小板聚集率均明显高于正常组(P<0.01);治疗5d后,治疗组的患儿显效率、总有效率均明显高于对照组(P<0.01),同时治疗组患儿血小板聚集率较对照组显著下降(P<0.05),而对照组患儿治疗前后血小板聚集率无显著性差异(P>0.05)。结论复方丹参注射液湿敷联合氦氖激光治疗新生儿输液所致静脉炎效果优于50%硫酸镁湿敷联合氦氖激光治疗,值得在临床推广应用。复方丹参注射液能降低新生儿输液所致静脉炎患儿血小板聚集率,抑制效应可能是复方丹参注射液治疗新生儿输液所致静脉炎的重要机制。
Objective To observe the clinical effect and mechanism of Fufang Danshen injection wet compress combined with He-Ne laser in the treatment of phlebitis induced by infusion in neonates. Methods Eighty neonates with phlebitis caused by infusion were divided into two groups: randomized dosing group (n = 40), wet compress with compound Danshen injection combined with He-Ne laser (n = 40) The combined He-Ne laser treatment for the control group (n = 40) for 5d treatment, at the beginning of treatment, the clinical evaluation on the 6th day, at the same time detection of platelet aggregation rate. Results Before treatment, platelet aggregation rate in infants with phlebitis caused by neonatal infusion was significantly higher than that in normal group (P <0.01). After 5 days of treatment, the effective rate and total effective rate of children in treatment group were significantly higher than those in control group P <0.01). The platelet aggregation rate in the treatment group was significantly lower than that in the control group (P <0.05), while the control group had no significant difference in platelet aggregation rate before and after treatment (P> 0.05). Conclusion The compound Danshen injection wet compress combined with He-Ne laser treatment of neonatal phlebitis caused by infusion is better than 50% magnesium sulfate wet compress combined with He-Ne laser treatment, it is worth in the clinical application. Compound Danshen injection can reduce neonatal phlebitis caused by infusion of platelet aggregation in children, the inhibitory effect may be compound Danshen injection treatment of neonatal phlebitis caused by an important mechanism of infusion.