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目的：验证来氟米特（ｌｅｆｌｕｎｏｍ ｉｄｅ）对同种异体急性排斥反应的抑制作用。方法：６０ 只成年 Ｌｅｗ ｉｓ 雄性大鼠作为受体， Ａ Ｃ Ｉ大鼠作为供体，分别行原位肝脏、小肠、肾脏以及异位心脏、胰腺移植。除对照组外，给予每只受体来氟米特５ ｍ ｇ·ｋｇ－ １·ｄ－ １ 治疗１４ ｄ。结果：与对照组比较，来氟米特可显著延长受体及移植物存活时间。其中，来氟米特可将 ２／６ 肾移植受体及５／５ 肝移植受体存活时间延长至１００ ｄ 以上。结论：来氟米特可显著延缓大鼠同种异体小肠、心脏及胰腺器官移植排斥反应；可有效控制肝脏及肾脏移植排斥反应。
Objective: To verify the inhibitory effect of leflunom ide on allogeneic acute rejection. METHODS: Sixty adult Lew is male rats and A C I rats served as donors for liver, small intestine, kidney, ectopic heart and pancreas transplantation respectively. In addition to the control group, each recipient received leflunomide 5 m g · kg -1 · d -1 for 14 days. Results: Leflunomide significantly prolonged the survival of recipients and grafts compared with the control group. Among them, leflunomide 2/6 renal transplant recipients and 5/5 liver transplant recipients survival time extended to more than 100 d. CONCLUSION: Leflunomide can delay the allograft rejection of allogeneic small intestine, heart and pancreas in rats, and can effectively control the rejection of liver and kidney transplantation.