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目的观察异甘草酸镁注射液在慢性乙型肝炎治疗中的临床疗效。方法 136例慢性乙肝患者随机分为治疗组和对照组,在综合治疗基础上治疗组68例采用异甘草酸镁注射液(天晴甘美)150 mg加入到5%～10%葡萄糖注射液250 ml中静脉滴注,对照组68例采用复方甘草酸苷注射液(美能)100 ml加入到5%～10%葡萄糖注射液250 ml中静脉滴注,两组均1次/d,连续使用4周,治疗结束后进行疗效评估。结果两组患者症状、体征均明显恢复,但差异无统计学意义。治疗组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(TB IL)的恢复明显优于对照组(P<0.01)。两组治疗过程中均未出现明显不良反应。结论异甘草酸镁注射液可明显改善慢性乙型肝炎患者的临床症状和肝功生化指标,无不良反应,有临床推广应用价值。
Objective To observe the clinical effect of magnesium isrimazole injection in the treatment of chronic hepatitis B. Methods One hundred and sixty-six patients with chronic hepatitis B were randomly divided into treatment group and control group. On the basis of comprehensive treatment, 68 patients in the treatment group were treated with 250 mg intravenous injection of 5% ~ 10% dextrose injection (150 mg) Note, the control group of 68 patients with compound glycyrrhizin injection (the United States) 100 ml added to 5% ~ 10% glucose injection 250 ml intravenous infusion, both groups were 1 / d, continuous use for 4 weeks, the treatment ended After the efficacy evaluation. Results The symptoms and signs of both groups were significantly recovered, but the difference was not statistically significant. Recovery of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total serum bilirubin (TBIL) in the treatment group was significantly better than that in the control group (P <0.01). No significant adverse reactions occurred in both groups during the course of treatment. Conclusion Magnesium isonipecotate injection can significantly improve the clinical symptoms and liver biochemical indicators of patients with chronic hepatitis B, no adverse reactions, clinical application value.