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目的:通过对大白鼠血液流变学和红细胞超氧化物歧化酶(SOD)、血浆丙二醛(MDA)的实验,为消瘀康胶囊提供药效学研究依据。方法:取试验用大白鼠随机分为三个组:对照组、阳性对照组和消瘀康胶囊组;对照组灌服生理盐水,阳性对照组灌服复方丹参胶囊溶液,实验组灌服消瘀康胶囊溶液(剂量为10.0g/kg体重),各组动物分别灌服至10日,颈动脉取动脉血检测血液流变学指标和氧自由基代谢指标。结果:通过对大白鼠血液流变学和红细胞超氧化物歧化酶(SOD)、血浆丙二醛(MDA)的实验,为消瘀康胶囊提供药效学研究依据。结论:消瘀康胶囊具有降低血液黏度,改善红细胞变形能力的作用,其作用优于阳性对照;消瘀康胶囊和阳性对照组同时具有升高大鼠体内红细胞超氧化物歧化酶(SOD)、血浆丙二醛(MDA)水平的作用,尤以消瘀康胶囊组作用为著。
OBJECTIVE: To provide a pharmacodynamic basis for Xiaoyukang Capsule through experiments on hemorheology, erythrocyte superoxide dismutase (SOD) and malondialdehyde (MDA) in rats. Methods: The rats were randomly divided into three groups: control group, positive control group and Xiaoyuankang capsule group. The control group was given normal saline, and the positive control group was given Fufang Danshen capsule solution. Kang capsule solution (dose of 10.0g / kg body weight), each group of animals were fed to 10 days, the carotid artery blood samples were measured for hemorheology and oxygen free radical metabolism. Results: Based on the experimental data of hemorheology, erythrocyte superoxide dismutase (SOD) and plasma malondialdehyde (MDA) in rats, pharmacokinetic study was provided for Xiaoyu capsule. Conclusion: Xiaoyukang capsule has the effects of lowering blood viscosity and improving the deformability of erythrocytes, and its effect is better than that of positive control. Xiaoyukang capsule and positive control group also have the effects of increasing the content of erythrocyte superoxide dismutase (SOD), plasma Malondialdehyde (MDA) levels, especially in the role of Xiaoyu Capsule.