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结直肠癌是目前我国发病率及死亡率最高的恶性肿瘤之一。随着精准医疗理念及对肿瘤相关分子标志物研究的逐年深入，合理的检测及应用结直肠癌相关分子标志物已经成为目前临床实践的重要部分。为了提高临床医师对结直肠癌分子标志物的了解及应用，中国临床肿瘤学会（CSCO）结直肠癌专家委员会组织相关领域专家，根据近年的国内外临床研究及实际诊疗经验，经专家组反复修改讨论，撰写了结直肠癌分子标志物临床检测的专家共识，旨在为临床医师提供参考及指导，为结直肠癌患者提供更加精准、有效的治疗。“,”Colorectal cancer is one of the malignant tumors with the highest morbidity and mortality in China. With the research of precision medicine concept and tumor-related molecular markers, appropriate detection and application of colorectal cancer-related molecular markers has become an important part of current clinical practice. In order to effectively solve the current clinical problems and improve clinicians' understanding and application of molecular markers on colorectal cancer, the Chinese Society of Clinical Oncology(CSCO) Colorectal Cancer Expert Committee organized experts in related fields to write an expert consensus on molecular markers of colorectal cancer based on recent domestic and international clinical trial and clinical experience. The consensus mainly provides guidance on testing specimens, molecular markers and testing methods, and interpretation of testing results. It aims to provide clinicians with standardized clinical reference for diagnosis and treatment, and standard and effective treatment for patients with colorectal cancer.