Occludin蛋白是紧密连接上的主要蛋白质之一,其功能状态与多种疾病的发生、发展密切相关。Oc-cludin蛋白在疾病中的作用及调控机制已成为研究热点。以下主要就近年来对occludin蛋白的调控和临床意义的进展作一综述。 Occludin protein is closely linked to one of the major proteins, the functional status and a variety of diseases are closely related to the development. Oc-cludin protein in the disease and its regulatory mechanism has become a research hotspot. The following mainly in recent years the occludin protein regulation and clinical significance of the progress are reviewed.