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肥胖是结直肠癌发病的危险因素,瘦素是ob基因的表达产物,主要来源于脂肪细胞,是重要的脂肪因子之一,被认为是肥胖和结直肠癌之间联系的重要角色。近年来对瘦素在结直肠癌的形成和进展中的作用及机制的研究对结直肠癌的诊断和治疗具有重要意义。
Obesity is a risk factor for the development of colorectal cancer. Leptin is the expression product of ob gene, which is mainly derived from adipocytes. It is one of the important adipokines and is considered as an important role in the link between obesity and colorectal cancer. In recent years, the role and mechanism of leptin in the formation and progression of colorectal cancer is of great significance for the diagnosis and treatment of colorectal cancer.