为了评估非类固醇抗炎药（ＮＳＡＩＤｓ）和幽门螺旋杆菌（Ｈｐ）在消化性溃疡病出血中的相互作用，对１０６例溃疡病出血患者进行了临床观察、Ｈｐ检测和病理学研究。结果表明，４１例（３８７％）溃疡病出血前有ＮＳＡＩＤｓ用药史，其中３６例Ｈｐ阳性，６５例（６１３％）无ＮＳＡＩＤｓ用药史，其中４２例Ｈｐ阳性，两者比较显示使用ＮＳＡＩＤｓ者的Ｈｐ阳性率较高（Ｐ＜００１）。组织学方面，Ｈｐ阳性的ＮＳＡＩＤｓ用药者主要表现为严重的慢性活动性胃炎，并常见胃粘膜局灶性坏死和微小糜烂形成，与Ｈｐ阳性的非ＮＳＡＩＤｓ用药者和Ｈｐ阴性的ＮＳＡＩＤｓ用药者比较，其胃粘膜受损更加严重。结果表明Ｈｐ感染者服用ＮＳＡＩＤｓ，显著增大了溃疡病出血的危险性 In order to assess the interaction of non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori (Hp) in peptic ulcer bleeding, clinical observation, Hp detection and pathology were performed in 106 patients with ulcer disease hemorrhage. The results showed that 41 cases (38.7%) had a history of NSAIDs before bleeding, of which 36 cases were Hp positive and 65 cases (613%) had no history of NSAIDs drug use, of which 42 cases were Hp positive. Hp positive rate was higher in NSAIDs (P <001). Histologically, Hp-positive patients with NSAIDs mainly manifested as severe chronic active gastritis, and common gastric mucosal focal necrosis and micro-erosion formation, compared with Hp-positive non-NSAIDs drug users and Hp-negative NSAIDs drug users, The damage to the gastric mucosa is more serious. The results showed that Hp infected patients taking NSAIDs, significantly increased the risk of bleeding ulcer