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目的观察脑梗死急性期降压治疗对临床预后的影响。方法将收缩压≥200mm Hg或者舒张压≥110mm Hg的60例患者随机分为治疗组和对照组各30例,治疗组用厄贝沙坦氢氯噻嗪降压,对照组第1天不使用降压药。观察2组患者发病2周的血压和神经功能缺损评分。结果 2组治疗后血压与治疗前相比明显下降,差异有统计学意义(P<0.05)。治疗组治疗第14天的神经功能评分较对照组明显改善,差异有统计学意义(P<0.05)。结论脑梗死急性期应用厄贝沙坦氢氯噻嗪对血压进行干预是安全的。
Objective To observe the effect of antihypertensive therapy on the prognosis of patients with acute cerebral infarction. Methods Sixty patients with systolic blood pressure ≥200 mm Hg or diastolic blood pressure ≥110 mm Hg were randomly divided into treatment group (30 cases) and control group (n = 30). The treatment group was treated with irbesartan hydrochloride hydrochlorothiazide, while the control group did not use antihypertensive drugs . The blood pressure and neurological deficit scores of two groups were observed 2 weeks after onset. Results After treatment, the blood pressure of the two groups was significantly lower than that before treatment, the difference was statistically significant (P <0.05). The score of neurological function of the treatment group on the 14th day was significantly improved compared with that of the control group (P <0.05). Conclusion It is safe to use irbesartan hydrochlorothiazide to interfere the blood pressure in the acute stage of cerebral infarction.