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采用甩尾潜伏期作为伤害感受的指标 ,用vonFrey纤维测量机械性痛觉超敏(allodynia) ,观察给大鼠脑室注射 (i.c .v .)痛稳素 (nocistatin)能否逆转孤啡肽 (orphaninFQ)的抗吗啡镇痛作用 ,以及脑室注射或脊髓蛛网膜下腔注射 (i.t.)痛稳素能否影响神经源性痛大鼠的机械性痛觉超敏 .结果表明 ,脑室注射痛稳素不影响大鼠的甩尾潜伏期 ,也不影响吗啡镇痛 ,脑室注射或脊髓蛛网膜下腔注射痛稳素也不影响神经损伤侧后肢的缩足阈值 .然而 ,脑室注射痛稳素能显著逆转孤啡肽的抗吗啡镇痛作用 .由此得出痛稳素在脑水平能逆转孤啡肽的抗吗啡镇痛作用 ,而在脑和脊髓水平均不抑制神经源性痛的机械性痛觉超敏 .
Using tail flick latency as an index of nociception, mechanical allodynia was measured with von Frey fibers and whether or nocistatin was injected intracerebroventricular (icv) into orphanin FQ Of anti-morphine analgesia and whether intraventricular or spinal subarachnoid (it) painkiller can affect mechanical hyperalgesia in neurogenic pain rats.The results show that intraventricular injection of aphrodisiac does not affect the large Rat tail flick latency did not affect morphine analgesia, intracerebroventricular injection or spinal subarachnoid injection of painkillers also did not affect the nerve injury side hind limb contractions threshold.However, intracerebroventricular injection of pain hormone can significantly reverse the orphanin peptide Of the anti-morphine analgesic effect, suggesting that aphrodisin can reverse the anti-morphine analgesic effect of orphanin at the brain level, but not the mechanical allodynia of neurogenic pain at the brain and spinal cord levels.