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目的:研究香枳和胃片对实验性大鼠胃黏膜损伤的保护作用。方法:将实验鼠分为阴性对照组(生理盐水)、香枳和胃片(高、中、低剂量)组和阳性对照组(雷尼替丁),观察香枳和胃片灌服后对无水乙醇所致和幽门结扎型胃黏膜损伤大鼠的影响。结果:与阴性对照组比较,香枳和胃片各剂量组均能明显减少胃液分泌量,降低胃酸总酸度(P<0.05),显著降低溃疡指数(P<0.05),低、中、高各剂量组溃疡抑制率分别达到44.92%,57.42%,64.76%。结论:香枳和胃片对实验性胃黏膜损伤有明显的保护作用。
Objective: To study the protective effect of Xiang-tian and stomach tablet on gastric mucosal lesion in experimental rats. Methods: The experimental rats were divided into negative control group (normal saline), Fragrant trifoliate orange and stomach tablet (high, middle and low dose) group and positive control group (ranitidine) Effect of absolute ethyl alcohol on pylorus - ligated gastric mucosa injury in rats. Results: Compared with the negative control group, all doses of Xiang Tio and Stomach Tablets could significantly reduce gastric secretion, reduce total acidity (P <0.05), significantly reduce the ulcer index (P <0.05), low, middle and high The inhibition rate of ulcer in dose group reached 44.92%, 57.42%, 64.76% respectively. Conclusion: Fragrant trifoliate orange and stomach tablet have significant protective effect on experimental gastric mucosal injury.