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目的 研究佝偻病患儿血清微量元素的含量及其比值的临床意义。方法 采用原子吸收光谱法 ,测定5 6例活动期佝偻病患儿、71例健康小儿血清微量元素锌、铜、铁、锰、钙和镁的含量 ,并计算它们的比值。结果 与健康儿童比较 ,佝偻病患儿血清Ca/Mg、Cu/Fe、Zn/Fe的比值下降 ,Cu/Zn比值升高 ,差异非常显著 (P <0 0 1)。佝偻病患儿血清钙、锌含量下降 ,佝偻病与血清钙、锌之间呈负相关关系 ,相关系数分别为 - 0 6 5 42和 - 0 16 83 ;血清铜、铁、镁含量高于正常儿 ;而锰含量两组之间无显著性差异。结论 除低钙外 ,低锌可能也参与了佝偻病的发生发展。在佝偻病的防治中 ,应注意微量元素的平衡 ,适当补充锌制剂
Objective To study the clinical significance of serum trace elements in patients with rickets and its ratio. Methods The contents of trace elements zinc, copper, iron, manganese, calcium and magnesium in 56 healthy children with rickets active and 71 healthy children were measured by atomic absorption spectrometry, and their ratios were calculated. Results Compared with healthy children, the serum Ca / Mg, Cu / Fe, Zn / Fe ratio decreased and the Cu / Zn ratio increased significantly in children with rickets (P <0.01). The levels of serum calcium and zinc in children with rickets were decreased. There was a negative correlation between rickets and serum calcium and zinc. The correlation coefficients were -06 5 42 and -0 16 83 respectively. The content of copper, iron and magnesium in serum were higher than those in normal children. The manganese content between the two groups no significant difference. Conclusion In addition to low calcium, low zinc may also be involved in the development of rickets. In the prevention and treatment of rickets, we should pay attention to the balance of trace elements, zinc supplementation appropriate