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为探讨精浆 Ｚｎ 、 Ｃｕ 与超氧化物歧化酶（ Ｓ Ｏ Ｄ） 含量的相关性，以及氧自由基对男性生育力的影响，采用电位溶出法和放射免疫分析法，对１０８ 例男性正常生育者和３５０ 例男性不育症患者的精浆 Ｚｎ 、 Ｃｕ ， Ｃｕ Ｚｎ Ｓ Ｏ Ｄ 含量进行了测定。其结果不育组精浆 Ｚｎ 、 Ｃｕ ， Ｃｕ Ｚｎ Ｓ Ｏ Ｄ 含量较生育组显著降低（ Ｐ＜ ０ ．００１） ；精浆 Ｃｕ Ｚｎ Ｓ Ｏ Ｄ 含量均随着 Ｚｎ 、 Ｃｕ 含量的降低而降低，其间呈一定程度的正相关（ Ｐ＜ ０ ．００１） 。在精浆缺乏 Ｚｎ 、 Ｃｕ 时，精浆 Ｃｕ Ｚｎ Ｓ Ｏ Ｄ 含量降低，氧自由基产生增加，精浆抗氧毒性能力下降，提示氧自由基与男性不育有关。
In order to investigate the correlation between the contents of Zn and Cu in semen and the content of SOD, and the effect of oxygen free radicals on the male fertility, 108 normal male fertility patients were treated by potentiometric stripping and radioimmunoassay And seminal plasma Zn, Cu, Cu Zn-S O D content in 350 male infertility patients. As a result, the contents of Zn, Cu and Cu Zn-S O in the seminal plasma of infertile group were significantly lower than those in the reproductive group (P <0.001). The content of Cu Zn-S O D in the seminal plasma decreased with the decrease of Zn and Cu contents Decreased, during which a certain degree of positive correlation (P <0 .001). In the absence of Zn and Cu in the seminal plasma, the contents of Cu ZnS O D in seminal plasma decreased, the production of oxygen free radicals increased, and the ability of seminal plasma to resist oxygen toxicity decreased, suggesting that oxygen free radicals were associated with male infertility.