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目的研究盐酸氨溴索和654-2联合应用治疗毛细支气管炎的临床疗效。方法将63例毛细支气管炎患儿随机分成两组,两组病例采用相同的综合治疗,治疗组(n=31)在综合治疗基础上加用盐酸氨溴索和654-2。结果治疗组与对照组治疗24 h后比较,PaO2明显上升(P<0.01),呼吸改善(P<0.01),心率及PaCO2明显降低(P<0.01);病程中观察比较,治疗组咳嗽、喘息症状消失,肺部体征消失及总住院时间均明显短于对照组(P<0.01);转归中比较,治疗组中7 h内治愈率显著高于对照组(P<0.01);结论盐酸氨溴索和654-2联合应用对毛细支气管炎有协同辅助治疗作用,可以加速病情恢复。
Objective To study the clinical efficacy of ambroxol hydrochloride combined with 654-2 in the treatment of bronchiolitis. Methods Sixty-three children with bronchiolitis were randomly divided into two groups. The two groups were treated with the same combination therapy. The treatment group (n = 31) was given ambroxol hydrochloride and 654-2 on the basis of comprehensive treatment. Results After treatment for 24 h, PaO2 was significantly increased (P <0.01), respiration was improved (P <0.01), heart rate and PaCO2 were significantly decreased in treatment group and control group (P <0.01). During the course of treatment, cough and wheezing Symptoms disappeared, lung signs disappeared and the total length of stay was significantly shorter than that of the control group (P <0.01). In the prognosis, the cure rate in the treatment group within 7 h was significantly higher than that in the control group (P <0.01) Bromine and 654-2 joint application of bronchitis have synergistic adjuvant treatment, can speed up the recovery.