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为了阐明重症肌无力（ＭＧ）患者中枢神经系统（ＣＮＳ）受损机制，本研究利用免疫组化和脑干听觉诱发电位仪观察了从ＭＧ患者血中提取的乙酰１胆碱受体抗体（ＡＣｈＲａｂ）与神经元烟碱型乙酰胆碱受体（神经－ｎＡＣｈＲ）之间的免疫结合反应及其对大鼠脑干听觉传递中枢功能的影响。结果：首次表明神经－ｎＡＣｈＲ样阳性免疫结合反应弥散地分布于大鼠ＣＮＳ许多部位，如大鼠大脑皮层、脑干各颅神经运动核团、听神经核、脊髓前角运动元和小脑皮层等。注入脑室系统的ＡＣｈＲａｂ除了引起大鼠脑干听觉传递中枢功能障碍外，还引起ＭＧ动物模型样症状。提示：ＡＣｈＲａｂ可与ＣＮＳ中的神经－ｎＡＣｈＲ免疫交叉结合；ＡＣｈＲａｂ的病理作用不仅仅局限于神经肌接头处肌－ｎＡＣｈＲ，还可波及到ＣＮＳ中的神经－ｎＡＣｈＲ。
In order to clarify the mechanism of central nervous system (CNS) damage in patients with myasthenia gravis (MG), immunohistochemistry and brainstem auditory evoked potentials were used to observe the expression of acetylcholinylcholine receptor antibody (AChRab ) And neuronal nicotinic acetylcholine receptor (Nervous-nAChR) and its effect on central auditory function of brainstem auditory brainstem in rats. Results: For the first time, neuronal-nAChR-like immunoreactivity was diffusely distributed in many parts of rat CNS, such as rat cerebral cortex, cranial motor nuclei, auditory nucleus, anterior horn motor cells and cerebellar cortex. AChRab injected into the ventricular system in addition to causing central nervous system dysfunction in the brainstem auditory brainstem also causes MG animal model-like symptoms. It is suggested that AChRab can cross-bind with nerve-nAChR in CNS. The pathological effect of AChRab is not limited to muscle-nAChR at neuromuscular junction, but also to neuronal-nAChR in CNS.