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目的分析2005-2009年中国肿瘤登记地区肝癌疾病负担的变化趋势,为评价肝癌防治措施和制定防治策略提供科学依据。方法根据肿瘤登记年报肝癌相关发病死亡数据,计算每千人潜在减寿年(PYLL率)、标化每千人潜在减寿年(s PYLL率)、每千人伤残调整寿命年(DALY率)、相对比(RR)等指标连续性分析我国2005-2009年肝癌疾病负担的变化趋势。结果 2005-2009年全国肿瘤登记地区肝癌新发病例为90047例,发病率为27.63/10万;死亡病例为83976例,死亡率为25.77/10万。PYLL率(2.56/千人~2.65/千人)和DALY率(3.19/千人~3.30/千人)均维持在稳定水平。其中城镇地区疾病负担呈上升趋势,PYLL率和DALY率分别上升了9%和7%;农村地区疾病负担呈下降趋势,PYLL率和DALY率分别下降了22%和14%。农村与城镇发病率之比由1.45下降至1.24,死亡率之比由1.52下降至1.24,PYLL率之比由2.02下降至1.43,DALY率之比由1.73下降至1.39。肝癌的死亡发病比在2006年达峰值0.97,随后逐年下降。结论 2005-2009年我国肿瘤登记地区肝癌疾病负担仍较重,男性高于女性,农村高于城镇。农村与城镇肝癌疾病负担的差距正在缩小。
Objective To analyze the trend of burden of liver cancer in Chinese cancer registration areas from 2005 to 2009 and to provide scientific evidence for the evaluation of prevention and treatment measures and prevention and treatment strategies. Methods Based on the data of liver cancer related deaths recorded in the Tumor Registry, the potential life-years lost per 1,000 population (PYLL rate), the potential life-years lost per 1,000 population (s PYLL rate), the disability-adjusted life years per 1,000 population (DALY rate ), Relative ratio (RR) and other indicators of continuous analysis of China’s 2005-2009 trends in liver cancer burden. Results The number of newly diagnosed cases of liver cancer in the national tumor registration areas from 2005 to 2009 was 90,047 cases, with an incidence rate of 27.63 / 100 000; the number of deaths was 83,976 and the death rate was 25.77 / 100,000. PYLL rates (2.56 per thousand to 2.65 per thousand) and DALY rates (3.19 per thousand per 3.30 per thousand) remained stable. The burden of disease in urban areas showed an upward trend, with PYLL rates and DALY rates rising by 9% and 7% respectively. The burden of disease in rural areas showed a downward trend, with PYLL rates and DALY rates declining by 22% and 14% respectively. The ratio of rural to urban incidence decreased from 1.45 to 1.24, the mortality rate dropped from 1.52 to 1.24, the PYLL ratio dropped from 2.02 to 1.43, and the DALY ratio dropped from 1.73 to 1.39. The incidence of liver cancer incidence in 2006 reached a peak of 0.97, then declined year by year. Conclusions From 2005 to 2009, the burden of liver cancer in China’s cancer registration area is still relatively high, with men being higher than women and rural areas being higher than those in cities and towns. The gap between rural and urban liver cancer burden is shrinking.