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在危重的足月新生儿,颅内出血(ICH)常被脑CT和脑超声波检查所发现。根据出血类型和诊断方法的不同,ICH的发病率为16～38%。一些与早产儿脑室周围出血(PVH)有关的因素也经常存在于足月ICH患儿的围产史中。例如:窒息、高钠血症、低氧血症、酸中毒和血粘滞性过高等情况亦常出现在足月儿ICH的报告中。临床医生注意到:因胎粪吸入、败血症、RDS,膈疝和DIC导致持续肺动脉高压(PPH)的成熟新生儿ICH发病率增高;另外,PPH患儿有与早产儿PVH有关的因素,如窒息、酸中毒、气胸、治疗中的过度换气和血管活性药等因素是否使PPH患儿发生ICH的危险增加。方法研究包括35名PPH患儿,PPH诊断包括:未明原因的低氧血症,FiO_2>0.95吸氧时PO_2<100
In critically ill term neonates, intracranial hemorrhage (ICH) is often detected by brain CT and brain sonography. According to the type of bleeding and diagnostic methods, the incidence of ICH is 16 to 38%. Some of the factors associated with periventricular hemorrhage (PVH) in preterm infants are also frequently present in the perinatal history of full-term ICH. For example: asphyxia, hypernatremia, hypoxemia, acidosis and hyperviscosity of blood are also often reported in term ICH. Clinicians note that the incidence of ICH in mature neonates with persistent pulmonary hypertension (PPH) is increased due to meconium aspiration, sepsis, RDS, diaphragmatic hernia and DIC. In addition, there are factors associated with PVH in preterm infants, such as asphyxia, Acidosis, pneumothorax, hyperventilation in therapy, and vasoactive agents increase the risk of ICH in children with PPH. METHODS: A total of 35 children with PPH were included in the study. PPH diagnosis included unexplained hypoxemia, FiO 2> 0.95 PO 2 <100