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为了解肝硬化患者血浆内皮素水平的变化与门脉高压的关系，用特异性放射免疫分析法测定４６例肝硬化及３０例正常人血浆内皮素含量，Ｂ超测定门静脉直径。４６例肝硬化患者血浆内皮素水平（８２．６８±２６．０９ｐｇ／ｍｌ）明显高于对照组（５０．８±７．５８ｐｇ／ｍｌ，Ｐ＜０．０５）。其中２４例Ｃｈｉｌｄ－ｐｕｇｈＢ级（７９ｔ１９．２７ｐｇ／ｍｌ）和１４例ｃｈｉｌｄ－ｐｕｇｈＣ级（９４．５５±２４．３ｐｇ／ｍｌ）血浆内皮素水平明显高于８例ｃｈｉｌｄ－ｐｕｇｈＡ级（５７０５±１０．９６ｐｇ／ｍｌＰ＜０．０５和Ｐ＜０．０１）。４３例肝硬化患者血浆ＥＴ水平与门静脉直径有明显相关性（ｒ＝０．７６４Ｐ＜０．００１）。结果提示肝硬化患者血浆内皮素水平随肝功能损害程度加重而升高、其与门脉高压的产生有一定关系。
To understand the relationship between plasma endothelin level and portal hypertension in cirrhotic patients, the levels of plasma endothelin in 46 cases of cirrhosis and 30 normal subjects were determined by radioimmunoassay and the portal vein diameter was measured by B ultrasound. The plasma endothelin levels in 46 patients with cirrhosis (82.68 ± 26.09pg / ml) were significantly higher than those in the control group (50.8 ± 7.58pg / ml, P <0.05). The level of plasma endothelin in 24 cases of Child-pughB grade (79t19.27pg / ml) and 14 cases of child-pughC grade (94.55 ± 24.3pg / ml) was significantly higher than that in 8 cases of child-pugh class A (5705 ± 10. 96 pg / ml P <0.05 and P <0.01). Plasma ET levels in 43 patients with cirrhosis were significantly correlated with portal vein diameter (r = 0.764 P <0.001). The results suggest that plasma endothelin levels in patients with cirrhosis increase with the severity of liver dysfunction, which is related to the occurrence of portal hypertension.