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人流感病毒A/Los Angles/2/87株(A/LA/2/87)和鸟流感病毒A/Mallard/NY/78株既能在鸟组织培养,也能在哺乳动物组织培养中增殖,但它们的单基因重排病毒PB_2SGR却具有宿主范围的限制性(hr)表型特征,即能在鸟组织中有效地增殖而在哺乳动物组织中增殖受限。该表型和它在鼠猴和人体内的呼吸道增殖受限也有关。PB_2SGR病毒的PB_2基因来自鸟流感病毒A/Mal-lard/NY/78,其余基因都从人流感病毒A/LA/2/87得到。作者研究了这一表型变异的
The human influenza virus A / Los Angles / 2/87 (A / LA / 2/87) and the avian influenza A / Mallard / NY / 78 strain can both be cultured in the bird and in mammalian tissue culture, However, their single gene rearrangement virus PB2SGR has a host-range restricted (hr) phenotype that efficiently propagates in bird tissues and has limited proliferation in mammalian tissues. This phenotype is also related to its limited respiratory tract proliferation in both rhesus monkeys and humans. The PB_2 gene of PB_2SGR virus is from avian influenza virus A / Mal-lard / NY / 78, and the rest of the genes are obtained from human influenza virus A / LA / 2/87. The authors studied this phenotypic variation