本文旨在通过模拟高原环境,观察缺氧、寒冷、运动等因素及复合作用对大鼠肺组织的水通道蛋白5(AQP5)表达和肺动脉压(PAP)的影响,探讨高原肺水肿的产生机制。作者将实验动物分为平原对照组(15℃,海拔330m);平原寒冷组(海拔330m,舱内温度白天8:00～20:00℃,夜间20:00～8:004℃);? The aim of this paper is to investigate the effects of hypoxia, cold, exercise and other factors on the expression of aquaporin 5 (AQP5) and pulmonary artery pressure (PAP) in the lung tissue of rats by simulating the plateau environment and to explore the mechanism of plateau pulmonary edema . The experimental animals were divided into plain control group (15 ℃, elevation 330m); plain cold group (elevation 330m, cabin temperature daytime 8: 00-20: 00 ℃, nighttime 20: 00-8: 004 ℃);