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目的 检测HIV阴性隐性梅毒患者外周血T淋巴细胞亚群及NK淋巴细胞的比例 ,并探讨其临床意义。方法 应用流式细胞仪检测 4 3例未经治疗的隐性梅毒患者和 4 6例已经数疗程驱梅治疗但RPR持续阳性 2年以上的隐性梅毒患者外周血T淋巴细胞亚群及NK淋巴细胞的比例 ,并与 30例健康人群的检测结果相对照。结果 1 未经治疗的隐性梅毒患者和已经治疗但RPR持续阳性 2年以上的隐性梅毒CD3 、CD4及NK淋巴细胞的比例分别与健康人群的检测结果相比 ,差异均无显著性 (P >0 0 5 ) ;未经治疗的隐性梅毒患者CD8淋巴细胞的比例明显高于对照组 (P <0 0 0 1) ;已经治疗但RPR持续阳性 2年以上的隐性梅毒患者CD8淋巴细胞的比例高于对照组 (P <0 0 5 ) ;未经治疗的隐性梅毒患者CD4/CD8的比率明显低于对照组 (P <0 0 0 1) ,而已经治疗但RPR持续阳性 2年以上的隐性梅毒患者CD4/CD8的比率与对照组相比差异无显著性 (P >0 0 5 ) ;2 未经治疗的隐性梅毒患者和已经治疗但RPR持续阳性 2年以上的隐性梅毒患者的检测结果相比 ,CD3 、CD4及NK淋巴细胞的比例及CD4/CD8的比率差异无显著性 (P >0 0 5 ) ;未经治疗梅毒患者CD8淋巴细胞比例高于已经治疗但RPR持续阳性 2年以上的隐性梅毒患者 (P <0 0 5 )。结论 未经治疗的隐性梅毒患者
Objective To detect the percentage of T lymphocyte subsets and NK lymphocytes in peripheral blood of patients with HIV-negative latent syphilis and to explore its clinical significance. Methods Flow cytometry was used to detect T lymphocyte subsets and NK lymphocytes in 43 cases of untreated latent syphilis and 46 cases of latent syphilis which has been treated for several months with RPR persisting for more than 2 years Cell ratio, and with 30 healthy people in the test results contrast. Results 1 The percentage of CD3, CD4 and NK lymphocytes in untreated patients with latent syphilis and those who have been treated but have persistent positive RPR for more than 2 years were not significantly different from those in healthy subjects (P > 0 0 5). The percentage of CD8 lymphocytes in untreated patients with latent syphilis was significantly higher than that in controls (P <0.01). CD8 lymphocytes in patients with latent syphilis that had been treated for more than 2 years (P <0.05). The percentage of CD4 / CD8 in untreated patients with latent syphilis was significantly lower than that in control group (P <0.01) There was no significant difference in the CD4 / CD8 ratio between the two groups (P> 0.05); 2 untreated patients with latent syphilis and those who had been treated for more than 2 years with persistent positive RPR There was no significant difference in the proportion of CD3, CD4 and NK lymphocytes and the ratio of CD4 / CD8 between the syphilis patients and the untreated syphilis patients (P> 0.05) Persistent syphilis patients who were positive for more than 2 years (P <0.05). Conclusions Untreated latent syphilis patients