成人呼吸窘迫综合征(ARDS)可继发于包括脓毒症在内的多种疾患,但目前尚不可能识别哪些患者将发生这一严重并发症。作者连续测定了血中6种标记物,试图研究它们在预测脓毒症患者发生ARDS中的价值。 患者和方法 脓毒症患者26例,于确定诊断时(oh)及6、12、24、48h采血。其中6例6～24h内发生ARDS,也于确诊ARDS时及6～24h内采血。另选15例健康人作为对照。锰超氧岐化酶、Ⅷ因子抗原及α_1-磷酸弹性蛋白酶复合物用ELISA法测定,过氧化氢酶通过极谱法测定其氧化产物来测定,谷胱甘肽过氧化 Adult respiratory distress syndrome (ARDS) can be secondary to a variety of conditions including sepsis, but it is not yet possible to identify which patients will develop this serious complication. The authors continuously measured 6 markers in the blood in an attempt to study their value in predicting ARDS in patients with sepsis. Patients and Methods Seventy-six patients with sepsis were enrolled and blood was collected at the time of confirming diagnosis (oh) and at 6, 12, 24, 48 hours. ARDS occurred in 6 cases within 6 ~ 24h and blood was also collected in 6 ~ 24h after the diagnosis of ARDS. Another 15 healthy people as a control. Manganese superoxide dismutase, factor VIII antigen and alpha 1 -phosphate elastase complex were assayed by ELISA, catalase was determined by polarography to determine its oxidation product, glutathione peroxidation