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目的：探讨心理干预与艾司西酞普兰治疗轻中度抑郁发作的临床疗效。方法将120例轻中度抑郁发作患者随机分为两组，研究组（58例）予以心理干预，对照组（62例）口服艾司西酞普兰治疗，治疗过程中脱落病例进入脱落治疗组，予以心理干预联合艾司西酞普兰治疗，观察24周。于治疗前后采用汉密顿抑郁量表评定临床疗效。结果治疗初期研究组脱落率为36．2％，对照组为12．9％，研究组脱落率显著高于对照组（ P＜0．01）。治疗后研究组与对照组汉密顿抑郁量表评分均较治疗前显著下降（ P＜0．05或0．01），对照组治疗2周、8周、12周末较研究组下降更显著（ P＜0．05或0．01），治疗24周末研究组与对照组总有效率均显著高于脱落治疗组（P＜0．01），研究组与对照组比较差异无显著性（P＞0．05）。结论心理干预治疗轻中度抑郁发作虽起效较缓慢，但远期治疗效果显著，与艾司西酞普兰疗效相当。“,”Objective To explore the efficacy of psychotherapy and escitalopram in mild to moderate de‐pressive episode .Methods A total of 120 patients with mild to moderate depressive episode were random‐ly divided into two groups ,research group (n=58) received psychotherapy and control group (n=62) took orally escitalopram ,drop‐out cases during treatment getting into drop‐out treatment group received psy‐chotherapy plus escitalopram ,and they were observed for 24 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) .Results In the early days of treatment dropout rate was respective‐ly 36 .2% in research group and 12 .9% in control group ,the former was significantly higher the latter (P<0 .01) .After treatment the HAMD scores of both groups lowered more significantly compared with pretreatment (P<0 .05 or 0 .01) ,so did those at the end of the 2nd ,8th and 12th week in control than re‐search group (P<0 .05 or 0 .01) .At the end of the 24th week total effective rate of both research and con‐trol group were significantly higher than that of drop‐out treatment group (P 0 .05) .Conclusion Although psychotherapy takes effect slower in mild to moderate depressive episode ,its long‐term efficacy is notable and equivalent to escitalopram .