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本文观察抗孕激素利洛司酮 (lilopristone ZK98734)对大鼠着床、子宫内膜 PGs含量及血浆孕酮含量的影响。结果显示 :(1 ) 5 mg/ kg ZK98734可明显抑制胚泡着床 (对照组着床率 72 .5 0± 5 .6 8% ;ZK98734组 43.30± 3.86 % ) ;(2 ) ZK98734可促使子宫内膜内源性PGE2 和 PGF2α含量增加 ,5 mg/ kg、1 6 .5 mg/ kg和 2 5 mg/ kg三种剂量呈正相关剂量效应关系 ;(3) ZK98734明显降低血浆孕酮水平 ,三种剂量呈负相关剂量效应关系。提示 :ZK98734可能通过改变着床前子宫孕酮和前列腺素之间的精细平衡 ,干扰着床前子宫“静态”的生理环境 ,不利于胚泡在子宫内附着和发育 ,从而导致着床率降低
This article observes the effect of lilopristone ZK98734 on implantation, endometrial PGs content and plasma progesterone content in rats. The results showed that: (1) ZK98734 at 5 mg / kg significantly inhibited blastocyst implantation (72.500 ± 5.68% in control group and 43.30 ± 3.86% in ZK98734 group); (2) Endogenous endogenous PGE2 and PGF2α levels increased, 5 mg / kg, 16.5 mg / kg and 25 mg / kg three doses were positively correlated dose-response relationship; (3) ZK98734 significantly lower plasma progesterone levels, three The dose was negatively correlated with dose-response. Tip: ZK98734 may interfere with the “static” physiological environment of the uterus before implantation by changing the fine balance between uterine progesterone and prostaglandin before implantation, which is not conducive to the attachment and development of blastocysts in the uterus, resulting in the reduction of implantation rate