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目的分析妊娠合并艾森曼格综合征患者临床特征及妊娠结局,总结临床治疗策略。方法回顾性分析2009年1月至2015年12月四川大学华西第二医院收治的29例妊娠合并艾森曼格综合征患者的临床特征及妊娠结局。结果孕妇先天性心脏病类型以室间隔缺损为主(21例),同时多合并有瓣膜病变(21例),心律失常(19例)和电轴偏移(21例)。孕妇在院死亡3例。胚胎停止发育、死胎或引产共10例,出生胎儿19例,无生机儿2例,存活17例。结论妊娠合并艾森曼格综合征母婴死亡率高,是妊娠的禁忌症;治疗策略包括早诊断早治疗,围生期严密监护和个性化治疗,尤其注意产时和产后监护治疗。
Objective To analyze the clinical characteristics and pregnancy outcome of patients with pregnancy complicated with Eisenmenger syndrome and to summarize the clinical treatment strategies. Methods The clinical features and pregnancy outcomes of 29 pregnant women with Eisenmenger’s syndrome who were admitted to West Second Hospital of Sichuan University from January 2009 to December 2015 were retrospectively analyzed. Results The main types of congenital heart disease in pregnant women were ventricular septal defect (21 cases), valvular disease (21 cases), arrhythmia (19 cases) and axial deviation (21 cases). 3 pregnant women died in hospital. Fetal development stopped, 10 cases of stillbirth or induction of labor, 19 cases of fetal birth, 2 cases of non-living children, 17 cases of survival. Conclusions Pregnancy with Eisenmenger syndrome is a contraindication to pregnancy due to high maternal and infant mortality rates. Treatment strategies include early diagnosis and early treatment, intensive care during perinatal period, and personalized treatment, with particular attention to labor and postnatal care.