脓毒症是外科危重患者常见的并发症,进一步发展可导致脓毒性休克、多器官功能障碍综合征,病死率高。脓毒症继发相对肾上腺皮质功能不全己广为认同,并且认为它直接影响患者的的治疗、生存时间。但多年来缺乏统一的诊断标准,因而各家报道的脓毒症合并相对肾上腺皮质功能不全的发病率有很大差异。糖皮质激素作为脓毒症的辅助治疗半个世纪以来一直存在很大争议。 Sepsis is a common complication in critically ill surgical patients, and further development can lead to septic shock, multiple organ dysfunction syndrome and high mortality. Sepsis secondary to adrenal insufficiency has been widely recognized, and that it directly affects the patient’s treatment, survival time. However, the lack of a unified diagnostic criteria over the years, so each reported sepsis relative to the incidence of adrenal insufficiency have very different. Glucocorticoids have been the subject of controversy for more than half a century as adjuvant therapy for sepsis.