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目的 探讨在急性肺血栓栓塞症 (APE)发病中的组织型纤溶酶原激活物 (tPA)及其抑制剂 1(PAI 1)的血浆含量、作用及其该病诊断中的意义。方法 对 4 4例APE患者和 5 6例健康正常对照者应用酶联免疫吸附双抗体夹心法 (ELISA法 )定量测定血浆tPA和PAI 1抗原水平。结果 与正常对照组 (tPA含量为 11 0 5ng/ml和PAI 1含量为 6 1 31ng/ml)相比 ,APE组的tPA含量 (33 88ng/ml)和PAI 1含量(111 5 0ng/ml)较高 ,两组间差异有显著性。在急性肺血栓栓塞症的疾病诊断中 ,tPA和PAI 1的血浆含量合理诊断截断点分别为 2 1 7ng/ml和 79 4ng/ml。结论 急性肺血栓栓塞症的发病是由于PAI l抗原产生和释放增多 ,而非tPA抗原释放或产生不足所致。tPA和PAI 1抗原血浆含量测定在APE的疾病诊断中具有重要意义
Objective To investigate the plasma levels of tissue plasminogen activator (tPA) and its inhibitor 1 (PAI 1) in the pathogenesis of acute pulmonary thromboembolism (APE) and its significance in the diagnosis of the disease. Methods Serum levels of tPA and PAI 1 were quantitatively determined by ELISA in 44 APE patients and 56 healthy controls. Results The levels of tPA (33 88 ng / ml) and PAI 1 (111 5 0 ng / ml) in the APE group were significantly higher than those in the normal control group (tPA level of 110 5 ng / ml and PAI 1 level of 6 1 31 ng / Higher, the difference between the two groups was significant. In the diagnosis of acute pulmonary thromboembolism, the cut-off points for tPA and PAI 1 in plasma were 21 7 ng / ml and 79 4 ng / ml, respectively. Conclusion The incidence of acute pulmonary thromboembolism is due to the increased production and release of PAI l antigen, but not the release or deficiency of tPA antigen. Plasma levels of tPA and PAI 1 antigens are of great importance in the diagnosis of APE disease