论文部分内容阅读
目的探讨慢性乙型肝炎、肝硬化患者凝血功能与临床分型及乙肝病毒脱氧核糖核酸(HBV DNA)定量检测的关系。方法选取205例慢性乙型肝炎及肝硬化患者为观察组,同时选取44名健康体检者为对照组。比较各临床分型患者组的凝血酶原时间(PT)、国际标准化比值(INR)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)和血小板(PLT),并分析HBV DNA阴性和阳性患者各凝血指标的差异。结果 PT随着临床分型加重而升高,FIB则反之下降、INR和APTT在重度慢性乙型肝炎及肝硬化组显著增加,PLT只有在肝硬化患者中显著下降,统计学差异显著(P<0.05)。与HBV DNA阴性患者比较,阳性患者PT明显升高,FIB和PLT显著下降。结论慢性乙肝患者凝血功能障碍随着临床分型加重逐渐加重。当HBVDNA定量阳性时PT显著延长,FIB,PLT显著降低,应注意监测凝血功能变化,防止出现严重出血。
Objective To investigate the relationship between coagulation function and clinical classification and quantitative detection of hepatitis B virus DNA (HBV DNA) in patients with chronic hepatitis B and cirrhosis. Methods Totally 205 patients with chronic hepatitis B and cirrhosis were selected as the observation group and 44 healthy subjects were selected as the control group. Prothrombin time (PT), international normalized ratio (INR), fibrinogen (FIB), activated partial thromboplastin time (APTT) and platelet count (PLT) And positive patients with different indicators of coagulation. Results PT increased with the increase of clinical classification, FIB decreased conversely, INR and APTT increased significantly in patients with severe chronic hepatitis B and cirrhosis, PLT decreased only significantly in patients with cirrhosis, the difference was statistically significant (P < 0.05). Compared with HBV DNA-negative patients, PT in positive patients increased significantly, and FIB and PLT decreased significantly. Conclusion The coagulation dysfunction in patients with chronic hepatitis B aggravate gradually with the increase of clinical classification. When HBVDNA positive quantitative PT prolonged, FIB, PLT decreased significantly, should pay attention to monitoring changes in coagulation, to prevent the occurrence of severe bleeding.