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目的 :采用磁共振 (MR)首过灌注成像分析急性心肌梗死 (AMI)心肌首过灌注特点 ,评价病变心肌组织血流灌注治疗效果。方法 :AMI患者 16例 ,正常对照组 8例。采用TurboFLASH序列行MR首过灌注及延迟成像扫描 ,绘制左心室各壁心肌信号强度 时间曲线 ,分析病变心肌信号强度 时间曲线特点。结果 :AMI未溶栓者首过不强化 ,延迟扫描信号强度高于正常心肌 ,曲线上升时间、上升斜率、峰值时间和对比增强率明显低于正常心肌 ,峰值信号强度仅为正常心肌的 (5 4 .5± 12 .0 ) %。溶栓再灌注者首过及延迟均强化 ,延迟扫描时病变心肌信号强度高于正常心肌 ,信号强度 时间曲线仅曲线上升时间延长 ,峰值信号强度可达正常心肌的 (90 .8±13.0 ) %。结论 :TurboFLASH序列可反映心肌首过灌注 ,分析心肌首过灌注有助于评价病变心肌血流灌注情况 ,评价溶栓疗效
OBJECTIVE: To analyze the characteristics of myocardial perfusion by first-pass magnetic resonance (MR) perfusion imaging in acute myocardial infarction (AMI) and to evaluate the therapeutic effect of perfusion of myocardial tissue. Methods: 16 AMI patients and 8 normal controls. The first pass of MR perfusion and delayed imaging scan of the left ventricle were performed by using the TurboFLASH sequence. The myocardial signal intensity time curves of the left ventricle were drawn, and the characteristics of the myocardial signal intensity time curve were analyzed. Results: The signal intensity of delayed scan was higher than that of normal myocardium. The curve rising time, rising slope, peak time and contrast enhancement rate were significantly lower than those in normal myocardium, the peak signal intensity was only normal myocardium (5 4 .5 ± 12 .0)%. The thrombolytic and reperfusion patients had the first pass and delayed enhancement. The signal intensity of delayed myocardial infarction was higher than that of normal myocardium, and the signal intensity time curve only prolonged the curve rise time. The peak signal intensity reached (90.8 ± 13.0)% of normal myocardium, . Conclusion: The TurboFLASH sequence can reflect the first-pass myocardial perfusion. Analyzing the first-pass perfusion of myocardium is helpful to evaluate the myocardial perfusion in diseased myocardium and evaluating the effect of thrombolytic therapy