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目的更好地开发利用姜黄素,并对其降解产物进行质量控制。方法利用NMR谱对姜黄素在丙酮溶液中、碱溶液中的降解产物进行鉴定;利用紫外分光光度法检测不同条件下姜黄素的稳定性。结果从姜黄素的日光照射降解产物中分得7个化合物,分别鉴定为香草醛(vanillin,1)、香草酸(vanillic acid,2)、2-羟基-香荚兰乙酮(2-hydroxyacetovanillone,3)、原儿茶醛(protocatechualde-hyde,4)、乙酰阿魏酮(acetoferulone,5)、反式阿魏酸(trans-ferulic acid,6)、顺式阿魏酸(cis-ferulicacid,7);从姜黄素的碱溶液降解产物中分得3个化合物,分别鉴定为香草醛、香草酸、反式阿魏酸。姜黄素在pH10以上的碱性溶液中、光照条件下、在路易斯碱溶液中吸光度减小速度明显加快。结论共分得7个已知的降解产物;姜黄素在酸性溶液中较稳定,在碱性溶液中稳定性下降。
Objective To develop and utilize curcumin better and to control the quality of its degradation products. Methods The degradation products of curcumin in acetone solution and alkali solution were identified by NMR spectroscopy. The stability of curcumin under different conditions was detected by UV spectrophotometry. Results Seven compounds were separated from the photochemical degradation products of curcumin and identified as vanillin (1), vanillic acid (2), 2-hydroxyacetovanillone 3, protocatechualde-hyde (4), acetoferulone (5), trans-ferulic acid (6), cis-ferulic acid ). Three compounds were isolated from the degradation products of curcumin in alkaline solution and identified as vanillin, vanillic acid and trans-ferulic acid respectively. Curcumin in pH10 above alkaline solution, light conditions, the Lewis base solution absorbance decreased significantly faster. CONCLUSIONS Seven known degradation products were classified; curcumin is more stable in acidic solution and less stable in alkaline solution.